Virginia Polytechnic Institute and State University Department of Animal and Poultry Sciences, Virginia
My research interest is to study the complex interplay between bacterial pathogens, microbiome and host immune system in gastrointestinal tract in human and animal. I have dedicated on establishing the mechanism implicated in food borne bacterial pathogen Campylobacter jejuni-induced intestinal inflammation and animal intestinal diseases. Over the years, I have made several important discoveries in this field of research including the elucidation of mTOR, PI3K/PI3Kγ, and NOD2 signaling in controlling campylobacteriosis. In addition, my work highlighted the key role of immune cells of macrophages and neutrophils in the pathogenesis. My research reveals the essential role of microbiome protecting against C. jejuni induced intestinal inflammation. More recently, I discovered that microbial metabolite secondary bile acids deoxycholic acid reduces C. jejuni animal colonization, animal-transmission-worsened campylobacteriosis, and Clostridium perfringens-induced necrotic enteritis. I am extending these novel findings and significantly contribute to unraveling the mechanism of microbiome as effective and sustainable antimicrobial free approaches against infectious diseases in human and animals.