Indexing & Abstracting
Dr. RAJA SINGH PAULRAJ
Marshall University,United States
My research experience have provided me with an excellent background in multiple biological disciplines specifically in biomedical sciences including molecular biology, biochemistry and gastrointestinal physiology. As a predoctoral student (M.Phil. in Endocrinology), I was able to conduct research in nimbolide effect on insulin like growth factor (IGF) system in androgen independent prostate cancer cell line (pc-3)”. As a doctoral student, my research focused on prostate cancer cell (PC-3) line with nimbolide for their anticancer molecular mechanism: Involvement of NF-?B, MAPK and PI3K-Akt pathways” using in vitro and molecular docking analysis. I used western blot, immunofluorescence and docking techniques in order to individually assess proteins of cell survival and proliferation of prostate cancer with anticancer drug nimbolide. As part of the postdoctoral training, I am currently involved in the proposed project with specific focus on understanding the molecular regulation of Na-bile acid co-transporter ASBT in in vivo rodent models as well as in IEC-18 cells in vitro. My postdoctoral training over the last year has given me the required expertise to handle the in vivo systems and the in vitro models of intestinal epithelial cells. In these systems, I will conduct functional and molecular studies to determine the regulation of ASBT using the proposed techniques. Under the expert supervision and guidance of the PIs in this grant, I believe that I will be elevating my potential as a scientist with the keen ability to analyze, interpret and extrapolate my experimental findings to a broader systemic relevance and significance.
Research Interest :
Cancer Biology, Molecular Biology, Physiology, Endocrinology, Gastroenterology, Food Science, Phytotherapy, Pharmacology, Drug Discovery.